Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
نویسندگان
چکیده
منابع مشابه
Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
BACKGROUND The identification of patients with high-risk atherosclerotic plaques prior to the manifestation of clinical events remains challenging. Recent findings question histology- and imaging-based definitions of the "vulnerable plaque," necessitating an improved approach for predicting onset of symptoms. METHODS We performed a proteomics comparison of the vascular extracellular matrix an...
متن کاملChanges related to age and cerebrovascular symptoms in the extracellular matrix of human carotid plaques.
BACKGROUND AND PURPOSE Many processes involved in the pathogenesis of atherosclerosis result in modifications of the extracellular matrix. These changes not only determine the mechanical stability of atherosclerotic lesions but can directly or indirectly influence further development of the lesions. The purpose of the present study was to compare the matrix composition of human carotid plaques ...
متن کاملUnstable carotid plaques exhibit raised matrix metalloproteinase-8 activity.
BACKGROUND The fibrous cap of atherosclerotic plaques is composed predominantly of type I and III collagen. Unstable carotid plaques are characterized by rupture of their cap, leading to thromboembolism and stroke. The proteolytic mechanisms causing plaque disruption are undefined, but the collagenolytic matrix metalloproteinase (MMP) -1, -8, and -13 may be implicated. The aim of this study was...
متن کاملProteomics Analysis of the Zebrafish Skeletal Extracellular Matrix
The extracellular matrix of the immature and mature skeleton is key to the development and function of the skeletal system. Notwithstanding its importance, it has been technically challenging to obtain a comprehensive picture of the changes in skeletal composition throughout the development of bone and cartilage. In this study, we analyzed the extracellular protein composition of the zebrafish ...
متن کاملTexture analysis of ultrasonic images of symptomatic carotid plaques can identify those plaques associated with ipsilateral embolic brain infarction.
OBJECTIVES The aim of our study was to determine the association between objective, computerised texture analysis of carotid plaque ultrasonic images and embolic CT-brain infarction in patients presenting with hemispheric neurological symptoms. DESIGN Cross-sectional study in patients with 50%-99% (ECST) carotid stenosis. PATIENTS AND METHODS Carotid plaque ultrasonic images (n=54, 26 with ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2017
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci86924